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境象生物为您提供KDR基因的突变检测服务。
新鲜或石蜡包埋的病理组织样本(≥100mg组织)
合同签订后30个工作日。
服务报告包含检测基因、检出位点、基因型、是否发生突变、突变等位基因频率等结果。
测序法
基因名称 | 基因全名 | 基因位置 | 外显子个数 | CDS长度 |
---|---|---|---|---|
KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 4q11-q12 | 30 | 约6055 bp |
基因摘要 | Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]. |