检测编号：SS0750423
服务项目
境象生物为您提供PIK3CA基因的突变检测服务。
样本要求
新鲜或石蜡包埋的病理组织样本（≥100mg组织）
服务周期
合同签订后30个工作日。
报告结果
服务报告包含检测基因、检出位点、基因型、是否发生突变、突变等位基因频率等结果。
检测方法
测序法
基因信息
| 基因名称 | 基因全名 | 基因位置 | 外显子个数 |
CDS长度 |
| PIK3CA |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
3q26.3 |
21 |
约3709 bp |
| 基因摘要 |
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]. |
相关文献
- Alakus H et al, Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin., Genome medicine;6(5):43, 2014, PubMed Link
- Crompton BD et al, The Genomic Landscape of Pediatric Ewing Sarcoma., Cancer discovery, 2014, PubMed Link
- Gao YB et al, Genetic landscape of esophageal squamous cell carcinoma., Nature genetics;46(10):1097-102, 2014, PubMed Link
- Gerlinger M et al, Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing., Nature genetics;46(3):225-33, 2014, PubMed Link
- Giannakis M et al, RNF43 is frequently mutated in colorectal and endometrial cancers., Nature genetics;46(12):1264-6, 2014, PubMed Link