芯片介绍

hsa-miR-138 miRNA靶基因表达谱PCR芯片精心选 择了hsa-miR-138 miRNA 可能的88个靶基因，采用精心设计和反复验证过的引物，运用实时荧光PCR方法帮您寻找miRNA真正的靶基因。应用2块靶基因PCR芯片分别对实验组和对照组样品进行分析，寻找表达有差异的基因，即可确定该miRNA的靶基因。如果您需要更改miRNA靶基因列表中的基因，也可以联系我们。

基因功能分类

根据Gene Ontology功能数据库和KEGG生物通路数据库对88个靶基因进行分类。

negative regulation of transcription from RNA polymerase II promoter ( GO:0000122 ):

ZFPM2, ZMYND11

blood vessel development ( GO:0001568 ):

CAV1, HIF1A, QKI, RBPJ, UBP1, VEZF1, ZFPM2

vasculogenesis ( GO:0001570 ):

CAV1, QKI, ZFPM2

vasculature development ( GO:0001944 ):

CAV1, HIF1A, QKI, RBPJ, UBP1, VEZF1, ZFPM2

transcription ( GO:0006350 ):

BAZ2B, BZW1, CNOT7, CNOT8, GTF2I, HIF1A, HMGA2, ILF3, KDM5A, JMJD1C, KHDRBS1, MEF2A, MXI1, NFIB, PURA, RB1CC1, RBPJ, SFPQ, SIRT1, SMAD2, SOX4, SUV420H1, TCF12, UBP1, VEZF1, ZFPM2, ZMYND11, ZNF292, ZNF451

regulation of transcription, DNA-dependent ( GO:0006355 ):

AFF1, CNOT7, CNOT8, CSDE1, DEK, DNAJB6, HIF1A, HMGA2, ILF3, JMJD1C, MEF2A, MYO6, NFIB, PURA, RBPJ, SIRT1, SMAD2, SOX4, TCF12, UBE2V1, UBP1, VEZF1, ZFPM2, ZMYND11

regulation of transcription from RNA polymerase II promoter ( GO:0006357 ):

CNOT7, DEK, HIF1A, MYO6, NFIB, SIRT1, SMAD2, TCF12, UBP1, VEZF1, ZFPM2, ZMYND11

protein amino acid phosphorylation ( GO:0006468 ):

AKT3, CDK19, CSNK1A1, MAPK6, PRPF4B, PTPN11, ROCK1, SMAD2, SPAG9, TNKS

phosphorus metabolic process ( GO:0006793 ):

AKT3, CDK19, CSNK1A1, MAPK6, PRPF4B, PTP4A1, PTP4A2, PTPN11, PTPRK, ROCK1, SACM1L, SLC2A1, SMAD2, SPAG9, TNKS

phosphate metabolic process ( GO:0006796 ):

AKT3, CDK19, CSNK1A1, MAPK6, PRPF4B, PTP4A1, PTP4A2, PTPN11, PTPRK, ROCK1, SACM1L, SLC2A1, SMAD2, SPAG9, TNKS

cell motion ( GO:0006928 ):

BTG1, CD2AP, HIF1A, LAMC1, MACF1, MSN, PAFAH1B1, PTPRK, ROCK1, SDCBP, TPM1, TPM4

response to oxidative stress ( GO:0006979 ):

HIF1A, PTPRK, TPM1

cell cycle ( GO:0007049 ):

CD2AP, CUL5, HMGA2, ILF3, KHDRBS1, MACF1, MAPK6, MAPRE1, PAFAH1B1, PCNP, PTP4A1, RB1CC1, SEH1L, SEPT11, SMC1A, STAG2, TNKS, ZMYND11, SMAD2, SMC1A, STAG2

heart development ( GO:0007507 ):

RB1CC1, RBPJ, SMAD2, SOX4, TPM1, ZFPM2

negative regulation of cell proliferation ( GO:0008285 ):

BTG1, CAV1, CNOT8, CUL5, MXI1, NFIB, PTPRK, SMAD2

macromolecule catabolic process ( GO:0009057 ):

CD2AP, CUL5, UBE2K, MGEA5, PCNP, RNF111, SUMO1, THRB, UBE2D3, UBE2H, UBE2V1, USP33, USP7, ZFP36L2

negative regulation of biosynthetic process ( GO:0009890 ):

CAV1, DNAJB6, ILF3, KHDRBS1, MGEA5, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of biosynthetic process ( GO:0009891 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MYO6, NFIB, SMAD2, SOX4, TNKS, ZFPM2

positive regulation of macromolecule biosynthetic process ( GO:0010557 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MYO6, NFIB, SMAD2, SOX4, TNKS, ZFPM2

negative regulation of macromolecule biosynthetic process ( GO:0010558 ):

DNAJB6, ILF3, KHDRBS1, MGEA5, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of macromolecule metabolic process ( GO:0010604 ):

AFF1, CAV1, CNOT7, HIF1A, ILF3, KDM5A, MGEA5, MYO6, NFIB, RB1CC1, SMAD2, SOX4, TNKS, ZFPM2

negative regulation of macromolecule metabolic process ( GO:0010605 ):

BNIP3L, CAV1, DNAJB6, ILF3, KHDRBS1, MGEA5, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of gene expression ( GO:0010628 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MYO6, NFIB, SMAD2, SOX4, ZFPM2

negative regulation of gene expression ( GO:0010629 ):

BNIP3L, DNAJB6, ILF3, KHDRBS1, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

mRNA metabolic process ( GO:0016071 ):

KHDRBS1, PRPF40A, PRPF4B, QKI, SMC1A, SYNCRIP, ZFP36L2

cell migration ( GO:0016477 ):

BTG1, CD2AP, HIF1A, LAMC1, MSN, PAFAH1B1, PTPRK, ROCK1, SDCBP

negative regulation of transcription ( GO:0016481 ):

DNAJB6, ILF3, KHDRBS1, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

chromatin modification ( GO:0016568 ):

KDM5A, SIRT1, SUV420H1

histone modification ( GO:0016570 ):

SIRT1

regulation of cell migration ( GO:0030334 ):

CLIC4, HIF1A, PTP4A1, PTPRK, SPAG9, TPM1

negative regulation of cellular biosynthetic process ( GO:0031327 ):

CAV1, DNAJB6, ILF3, KHDRBS1, MGEA5, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of cellular biosynthetic process ( GO:0031328 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MYO6, NFIB, SMAD2, SOX4, TNKS, ZFPM2

response to corticosteroid stimulus ( GO:0031960 ):

CAV1

regulation of locomotion ( GO:0040012 ):

CLIC4, HIF1A, PTP4A1, PTPRK, SPAG9, TPM1

regulation of cell proliferation ( GO:0042127 ):

BTG1, CAV1, CNOT8, CUL5, HIF1A, LAMC1, MXI1, NFIB, PTPRK, PURA, SIRT1, SMAD2, SOX4

cellular macromolecule catabolic process ( GO:0044265 ):

CD2AP, CUL5, UBE2K, PCNP, RNF111, SUMO1, THRB, UBE2D3, UBE2H, UBE2V1, USP33, USP7, ZFP36L2

regulation of transcription ( GO:0045449 ):

AFF1, BAZ2B, BTG1, BZW1, CNOT7, CNOT8, CSDE1, DEK, DNAJB6, GTF2I, HIF1A, HMGA2, ILF3, KDM5A, JMJD1C, KHDRBS1, MEF2A, MXI1, MYO6, NFIB, PTPRK, PURA, RB1CC1, RBPJ, SFPQ, SIRT1, SMAD2, SOX4, SUMO1, SUV420H1, TCF12, UBE2V1, UBP1, VEZF1, ZFPM2, ZMYND11, ZNF292, ZNF451

negative regulation of transcription, DNA-dependent ( GO:0045892 ):

DNAJB6, ILF3, PURA, RBPJ, SIRT1, SMAD2, ZFPM2, ZMYND11

positive regulation of transcription, DNA-dependent ( GO:0045893 ):

AFF1, CNOT7, HIF1A, ILF3, MYO6, NFIB, SMAD2, SOX4, ZFPM2

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic pro ( GO:0045934 ):

DNAJB6, ILF3, KHDRBS1, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic pro ( GO:0045935 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MGEA5, MYO6, NFIB, SMAD2, SOX4, TNKS, ZFPM2

positive regulation of transcription ( GO:0045941 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MYO6, NFIB, SMAD2, SOX4, ZFPM2

positive regulation of transcription from RNA polymerase II promoter ( GO:0045944 ):

CNOT7, HIF1A, MYO6, NFIB, SMAD2, ZFPM2

blood vessel morphogenesis ( GO:0048514 ):

CAV1, HIF1A, QKI, RBPJ, VEZF1, ZFPM2

cell motility ( GO:0048870 ):

BTG1, CD2AP, HIF1A, LAMC1, MSN, PAFAH1B1, PTPRK, ROCK1, SDCBP

positive regulation of developmental process ( GO:0051094 ):

BTG1, FNDC3B, HIF1A, SMAD2

positive regulation of cellular component organization ( GO:0051130 ):

CAV1, MGEA5, SMAD2, TNKS, TPM1

negative regulation of nitrogen compound metabolic process ( GO:0051172 ):

CAV1, DNAJB6, ILF3, KHDRBS1, PTPRK, PURA, RBPJ, SIRT1, SMAD2, SUMO1, UBP1, ZFPM2, ZMYND11

positive regulation of nitrogen compound metabolic process ( GO:0051173 ):

AFF1, CNOT7, HIF1A, ILF3, KDM5A, MGEA5, MYO6, NFIB, SMAD2, SOX4, TNKS, ZFPM2

regulation of RNA metabolic process ( GO:0051252 ):

AFF1, CNOT7, CNOT8, CSDE1, DEK, DNAJB6, HIF1A, HMGA2, ILF3, JMJD1C, MEF2A, MYO6, NFIB, PURA, RBPJ, SIRT1, SMAD2, SOX4, SYNCRIP, TCF12, UBE2V1, UBP1, VEZF1, ZFP36L2, ZFPM2, ZMYND11

negative regulation of RNA metabolic process ( GO:0051253 ):

DNAJB6, ILF3, PURA, RBPJ, SIRT1, SMAD2, ZFPM2, ZMYND11

positive regulation of RNA metabolic process ( GO:0051254 ):

AFF1, CNOT7, HIF1A, ILF3, MYO6, NFIB, SMAD2, SOX4, ZFPM2

regulation of cell motion ( GO:0051270 ):

CLIC4, HIF1A, PTP4A1, PTPRK, SPAG9, TPM1

cell division ( GO:0051301 ):

CD2AP, CDK19, HMGA2, MAPRE1, PAFAH1B1, ROCK1, SEH1L, SEPT11, SMC1A, STAG2

localization of cell ( GO:0051674 ):

BTG1, CD2AP, HIF1A, LAMC1, MSN, PAFAH1B1, PTPRK, ROCK1, SDCBP

ErbB signaling pathway ( hsa04012 ):

AKT3

Endocytosis ( hsa04144 ):

SH3GLB1

Apoptosis ( hsa04210 ):

AKT3

Vascular smooth muscle contraction ( hsa04270 ):

PPP1R12A

Wnt signaling pathway ( hsa04310 ):

CSNK1A1, PPP2R5E, ROCK1

TGF-beta signaling pathway ( hsa04350 ):

ROCK1, SMAD2, ZFYVE16

Axon guidance ( hsa04360 ):

ROCK1

Focal adhesion ( hsa04510 ):

CAV1, COL5A2, LAMC1, PPP1R12A, ROCK1

ECM-receptor interaction ( hsa04512 ):

COL5A2, LAMC1

Adipocytokine signaling pathway ( hsa04920 ):

AKT3, PTPN11

Epithelial cell signaling in Helicobacter pylori infection ( hsa05120 ):

PTPN11, TJP1

Pathways in cancer ( hsa05200 ):

AKT3, HIF1A, LAMC1, SMAD2

Renal cell carcinoma ( hsa05211 ):

HIF1A, PTPN11

Pancreatic cancer ( hsa05212 ):

AKT3, SMAD2

Prostate cancer ( hsa05215 ):

AKT3

Acute myeloid leukemia ( hsa05221 ):

AKT3

Small cell lung cancer ( hsa05222 ):

AKT3, LAMC1