芯片介绍

hsa-miR-21 miRNA靶基因表达谱PCR芯片精心选 择了hsa-miR-21 miRNA 可能的88个靶基因，采用精心设计和反复验证过的引物，运用实时荧光PCR方法帮您寻找miRNA真正的靶基因。应用2块靶基因PCR芯片分别对实验组和对照组样品进行分析，寻找表达有差异的基因，即可确定该miRNA的靶基因。如果您需要更改miRNA靶基因列表中的基因，也可以联系我们。

基因功能分类

根据Gene Ontology功能数据库和KEGG生物通路数据库对88个靶基因进行分类。

skeletal system development ( GO:0001501 ):

ACVR2A, ALX1, SMAD5, SOX5, TGFBR1, TNFRSF11B, TP63

gastrulation with mouth forming second ( GO:0001702 ):

ACVR2A, LRP6

regionalization ( GO:0003002 ):

ACVR2A, BMPR2, BTG2, ALX1, FOXG1, KIF3A, LRP6, TGFBR1, TP63

protein amino acid phosphorylation ( GO:0006468 ):

ACVR2A, BMPR2, CSNK1G1, EPHA4, ERG, IL1B, LATS1, MAP2, MAP3K8, MAPK10, MYO3A, NTRK2, PRKCE, TESK2, TGFBR1, THBS1

phosphorus metabolic process ( GO:0006793 ):

ACVR2A, BMPR2, CSNK1G1, DUSP5, EPHA4, ERG, IL1B, LATS1, MAP2, MAP3K8, MAPK10, MTMR12, MYO3A, NTRK2, PRKCE, TESK2, TGFBR1, THBS1

phosphate metabolic process ( GO:0006796 ):

ACVR2A, BMPR2, CSNK1G1, DUSP5, EPHA4, ERG, IL1B, LATS1, MAP2, MAP3K8, MAPK10, MTMR12, MYO3A, NTRK2, PRKCE, TESK2, TGFBR1, THBS1

inflammatory response ( GO:0006954 ):

C7, CCL20, CCR7, CHST1, CHST2, IL1B, OLR1, PTGER3, PTX3, THBS1, TLR4

enzyme linked receptor protein signaling pathway ( GO:0007167 ):

ACVR2A, BMPR2, EPHA4, FGF1, FGF5, FGF7, HPGD, KL, LTBP2, NTRK2, SKI, SMAD5, TGFBR1

transmembrane receptor protein serine/threonine kinase signaling pathway ( GO:0007178 ):

BMPR2, HPGD, LTBP2, SKI, SMAD5, TGFBR1

cell-cell signaling ( GO:0007267 ):

CCL20, COL4A4, CXCL14, EGR3, FASLG, FGF1, FGF5, GABRG2, GRAP2, GRM5, HAP1, IL1B, KCNMA1, NOVA1, NTRK2, PCLO, SLC5A7, SOX2, SPRY1, TOMM40, TP63

synaptic transmission ( GO:0007268 ):

COL4A4, EGR3, GABRG2, GRM5, HAP1, KCNMA1, NOVA1, PCLO, SLC5A7, TOMM40

pattern specification process ( GO:0007389 ):

ACVR2A, BMPR2, BTG2, ALX1, FOXG1, KIF3A, LRP6, SMAD5, SOSTDC1, TGFBR1, TP63

fibroblast growth factor receptor signaling pathway ( GO:0008543 ):

FGF1, FGF7, KL

response to wounding ( GO:0009611 ):

C7, CCL20, CCR7, CHST1, CHST2, FGF7, IL1B, ITGB3, KL, OLR1, PTGER3, PTX3, THBD, THBS1, TIMP3, TLR4

positive regulation of biosynthetic process ( GO:0009891 ):

BCL11B, ALX1, CREB5, IGF1, IL1B, NFAT5, PTX3, SMAD5, SOX11, SOX2, SOX5, TGFBR1, THBS1, TLR4, TOMM40, TP63, ZFPM2

glial cell differentiation ( GO:0010001 ):

IGF1, PLP1, SOX11

response to organic substance ( GO:0010033 ):

ADCY2, BTG2, CD48, FASLG, IL1B, KCNMA1, LATS1, PDE3A, PFKFB2, TAT, TGFBR1, THBD, THBS1, TIMP3, TLR4, TOMM40

response to metal ion ( GO:0010038 ):

CAPN3, CYBRD1, KCNMA1, TAT, THBS1, TNFRSF11B

positive regulation of macromolecule biosynthetic process ( GO:0010557 ):

BCL11B, ALX1, CREB5, IGF1, IL1B, NFAT5, SMAD5, SOX11, SOX2, SOX5, TGFBR1, THBS1, TLR4, TP63, ZFPM2

positive regulation of phosphorus metabolic process ( GO:0010562 ):

ACVR2A, BMPR2, IL1B, TGFBR1, THBS1, TLR4

positive regulation of macromolecule metabolic process ( GO:0010604 ):

ACVR2A, BCL11B, BMPR2, ALX1, CREB5, IGF1, IL1B, NFAT5, SMAD5, SOX11, SOX2, SOX5, TGFBR1, THBS1, TLR4, TOMM40, TP63, ZFPM2

positive regulation of gene expression ( GO:0010628 ):

BCL11B, ALX1, CREB5, NFAT5, SMAD5, SOX11, SOX2, SOX5, TGFBR1, TP63, ZFPM2

positive regulation of cell communication ( GO:0010647 ):

ACVR2A, FASLG, IGF1, IL1B, NTRK2, SOX2, TGFBR1, THBS1, TLR4, TP63

regulation of phosphate metabolic process ( GO:0019220 ):

ACVR2A, ADCY2, BMPR2, IGF1, IL1B, LATS1, PDGFD, PFKFB2, PRKCE, SPRY1, SPRY4, TGFBR1, THBS1, TLR4, TOMM40

transmission of nerve impulse ( GO:0019226 ):

CLDN1, COL4A4, EGR3, GRM5, HAP1, KCNMA1, KCNMB2, NOVA1, PCLO, PLP1, SCN8A, SLC5A7, TOMM40

regulation of action potential in neuron ( GO:0019228 ):

CLDN1, KCNMA1, KCNMB2, SCN8A

regulation of ossification ( GO:0030278 ):

BMPR2, KL, SKI, SMAD5, SOX2

BMP signaling pathway ( GO:0030509 ):

BMPR2, SKI, SMAD5

regulation of BMP signaling pathway ( GO:0030510 ):

ACVR2A, SKI, SOSTDC1

positive regulation of cellular biosynthetic process ( GO:0031328 ):

BCL11B, ALX1, CREB5, IGF1, IL1B, NFAT5, PTX3, SMAD5, SOX11, SOX2, SOX5, TGFBR1, THBS1, TLR4, TOMM40, TP63, ZFPM2

gliogenesis ( GO:0042063 ):

IGF1, PLP1, SOX11

regulation of phosphorylation ( GO:0042325 ):

ACVR2A, ADCY2, BMPR2, IGF1, IL1B, LATS1, PDGFD, PFKFB2, PRKCE, SPRY1, SPRY4, TGFBR1, THBS1, TLR4, TOMM40

positive regulation of phosphorylation ( GO:0042327 ):

ACVR2A, BMPR2, IL1B, TGFBR1, THBS1, TLR4

homeostatic process ( GO:0042592 ):

C7, CCR7, CLDN1, FGF7, IGF1, IL1B, KCNMA1, KCNMB2, PFKM, PTGER3, SCN8A, SLC12A6, SMAD5, TAL1, TOMM40

negative regulation of MAP kinase activity ( GO:0043407 ):

IL1B, SPRY1, SPRY4

cell fate commitment ( GO:0045165 ):

FGF1, SMAD5, SOX2, SOX5, SPRY1, TAL1, TGFBR1

negative regulation of cell differentiation ( GO:0045596 ):

FOXG1, ITGB3, PHOX2B, SKI, SOX2, TGFBR1, TLR4, TP63

regulation of osteoblast differentiation ( GO:0045667 ):

BMPR2, SKI, SMAD5, SOX2

positive regulation of transcription, DNA-dependent ( GO:0045893 ):

BCL11B, ALX1, CREB5, NFAT5, SMAD5, SOX11, SOX2, SOX5, TP63, ZFPM2

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic pro ( GO:0045935 ):

BCL11B, ALX1, CREB5, NFAT5, SMAD5, SOX11, SOX2, SOX5, TGFBR1, TOMM40, TP63, ZFPM2

positive regulation of phosphate metabolic process ( GO:0045937 ):

ACVR2A, BMPR2, IL1B, TGFBR1, THBS1, TLR4

positive regulation of transcription ( GO:0045941 ):

BCL11B, ALX1, CREB5, NFAT5, SMAD5, SOX11, SOX2, SOX5, TGFBR1, TP63, ZFPM2

positive regulation of transcription from RNA polymerase II promoter ( GO:0045944 ):

BCL11B, ALX1, NFAT5, SMAD5, SOX11, SOX2, SOX5, TP63, ZFPM2

embryonic morphogenesis ( GO:0048598 ):

ACVR2A, BMPR2, ALX1, FOXG1, LRP6, SKI, SOX2, TGFBR1, TP63

chemical homeostasis ( GO:0048878 ):

C7, CCR7, CLDN1, FGF7, IGF1, IL1B, KCNMA1, KCNMB2, PFKM, PLP1, PTGER3, SCN8A, SLC12A6, TOMM40

positive regulation of developmental process ( GO:0051094 ):

ACVR2A, BMPR2, FOXG1, IL1B, PHOX2B, RHOB, SMAD5, SOX2, TAL1, THBS1

positive regulation of nitrogen compound metabolic process ( GO:0051173 ):

BCL11B, ALX1, CREB5, IGF1, IL1B, NFAT5, PTX3, SMAD5, SOX11, SOX2, SOX5, TGFBR1, TOMM40, TP63, ZFPM2

regulation of phosphorus metabolic process ( GO:0051174 ):

ACVR2A, ADCY2, BMPR2, IGF1, IL1B, LATS1, PDGFD, PFKFB2, PRKCE, SPRY1, SPRY4, TGFBR1, THBS1, TLR4, TOMM40

positive regulation of RNA metabolic process ( GO:0051254 ):

BCL11B, ALX1, CREB5, NFAT5, SMAD5, SOX11, SOX2, SOX5, TP63, ZFPM2

Keratan sulfate biosynthesis ( hsa00533 ):

B3GNT1, CHST1

MAPK signaling pathway ( hsa04010 ):

FASLG, FGF1, FGF5, FGF7, IL1B, MAP3K8, MAPK10, NTRK2, TGFBR1

Cytokine-cytokine receptor interaction ( hsa04060 ):

ACVR2A, CCL20, CCR7, CXCL14, FASLG, IL1B, TGFBR1, TNFRSF11B

TGF-beta signaling pathway ( hsa04350 ):

BMPR2, LTBP1, SMAD5, TGFBR1, THBS1

ECM-receptor interaction ( hsa04512 ):

ITGB3, THBS1

Melanoma ( hsa05218 ):

FGF1, FGF7, IGF1, PDGFD