芯片介绍

hsa-miR-28-5p miRNA靶基因表达谱PCR芯片精心选 择了hsa-miR-28-5p miRNA 可能的88个靶基因，采用精心设计和反复验证过的引物，运用实时荧光PCR方法帮您寻找miRNA真正的靶基因。应用2块靶基因PCR芯片分别对实验组和对照组样品进行分析，寻找表达有差异的基因，即可确定该miRNA的靶基因。如果您需要更改miRNA靶基因列表中的基因，也可以联系我们。

基因功能分类

根据Gene Ontology功能数据库和KEGG生物通路数据库对88个靶基因进行分类。

cell cycle checkpoint ( GO:0000075 ):

BUB3, CCNG2, MAD2L1, MAPK14, PTPN11, SMC1A

M phase of mitotic cell cycle ( GO:0000087 ):

BUB3, CCNG2, HMGA2, MAD2L1, PAFAH1B1, SEH1L, SMC1A, USP9X

mitotic cell cycle ( GO:0000278 ):

BUB3, CCNG2, CUL5, HMGA2, MAD2L1, PAFAH1B1, PSME3, SEH1L, SMC1A, TNKS, USP9X

nuclear division ( GO:0000280 ):

BUB3, CCNG2, HMGA2, MAD2L1, PAFAH1B1, SEH1L, SMC1A, USP9X

chromatin organization ( GO:0006325 ):

BMI1, HMGA2, HMGB2, KDM3B, JMJD1C, MLL, MORF4L1, KAT6A, SIRT1, SMARCC1, TBL1XR1, TLK1, TSPYL1

regulation of transcription from RNA polymerase II promoter ( GO:0006357 ):

ATXN1, CBFB, CREB1, DR1, FOXO3, HMGB2, MAPK14, MLL, SIRT1, SMAD4, SMARCC1, TBL1XR1, TRIM27, VEZF1

ubiquitin-dependent protein catabolic process ( GO:0006511 ):

BUB3, CUL5, MAD2L1, PCNP, PSME3, RNF6, TBL1XR1, THRB, USP9X

phospholipid metabolic process ( GO:0006644 ):

PAFAH1B1, SACM1L, SH3GLB1

glycerophospholipid metabolic process ( GO:0006650 ):

PAFAH1B1, SACM1L, SH3GLB1

intracellular protein transport ( GO:0006886 ):

AP3S1, KPNB1, MACF1, NUP98, TLK1, YWHAH, YWHAZ

Golgi to endosome transport ( GO:0006895 ):

RAB14

apoptosis ( GO:0006915 ):

FOXO3, FXR1, HSPD1, KRAS, MCL1, MLL, NRAS, PAK2, RTN3, SH3GLB1, SIRT1

cytoskeleton organization ( GO:0007010 ):

CALD1, KRAS, MACF1, NRAS, PAFAH1B1, PAK2, SEH1L, SMC1A, TNKS, WIPF1

cell cycle ( GO:0007049 ):

BUB3, CALM1, CCNG2, CREBL2, CUL5, HMGA2, MACF1, MAD2L1, MLL, PAFAH1B1, PCNP, PSME3, SEH1L, SMC1A, TLK1, TNKS, USP9X, BUB3, MAD2L1, SMAD4, SMC1A, YWHAH, YWHAZ

chromosome segregation ( GO:0007059 ):

BUB3, MAD2L1, SEH1L, SMC1A

mitosis ( GO:0007067 ):

BUB3, CCNG2, HMGA2, MAD2L1, PAFAH1B1, SEH1L, SMC1A, USP9X

enzyme linked receptor protein signaling pathway ( GO:0007167 ):

AP3S1, CREB1, EPS15, JAK1, PTPN11, PTPRF, SMAD4, TGFBR2, USP9X

small GTPase mediated signal transduction ( GO:0007264 ):

ARF3, KRAS, MAPK14, NRAS, RAB14, RAB1A, RAP1B

protein localization ( GO:0008104 ):

AP3S1, ARF3, CANX, EPS15, KPNB1, MACF1, NUP98, POM121, RAB14, RAB1A, RDX, SEH1L, SH3GLB1, TLK1, TNKS, YWHAH, YWHAZ, ZDHHC17

cell death ( GO:0008219 ):

ATXN1, FOXO3, FXR1, HPRT1, HSPD1, KRAS, MCL1, MLL, NRAS, PAK2, PSME3, RTN3, SH3GLB1, SIRT1

response to organic substance ( GO:0010033 ):

AP3S1, CREB1, CREB3L2, GCH1, GNG12, HMGB2, HPRT1, HSPD1, KRAS, MAPK14, MAT2A, MCL1, NFE2L2, PTPN11, SDC1, TGFBR2

positive regulation of macromolecule biosynthetic process ( GO:0010557 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, KAT6A, NFE2L2, SMAD4, SMARCC1, TBL1XR1, TNKS, YWHAH

positive regulation of gene expression ( GO:0010628 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, KAT6A, NFE2L2, SMAD4, SMARCC1, TBL1XR1, YWHAH

regulation of cell death ( GO:0010941 ):

CREB1, CUL5, FOXO3, GCH1, HIPK1, HSPD1, KRAS, MCL1, NRAS, PTPRF, SH3GLB1, SIRT1, YWHAZ

positive regulation of cell death ( GO:0010942 ):

CUL5, FOXO3, GCH1, HIPK1, HSPD1, PTPRF, SH3GLB1

programmed cell death ( GO:0012501 ):

FOXO3, FXR1, HSPD1, KRAS, MCL1, MLL, NRAS, PAK2, RTN3, SH3GLB1, SIRT1

protein transport ( GO:0015031 ):

AP3S1, ARF3, CANX, EPS15, KPNB1, MACF1, NUP98, POM121, RAB14, RAB1A, SEH1L, TLK1, TNKS, YWHAH, YWHAZ, ZDHHC17

vesicle-mediated transport ( GO:0016192 ):

AP3S1, ARF3, GAPVD1, KRAS, NRAS, RAB14, RAB1A, RBM12, RTN3, TGFBR2, YWHAZ

death ( GO:0016265 ):

ATXN1, FOXO3, FXR1, HPRT1, HSPD1, KRAS, MCL1, MLL, NRAS, PAK2, PSME3, RTN3, SH3GLB1, SIRT1

chromatin modification ( GO:0016568 ):

BMI1, KDM3B, JMJD1C, MLL, MORF4L1, KAT6A, SIRT1, SMARCC1, TBL1XR1, TLK1

organophosphate metabolic process ( GO:0019637 ):

PAFAH1B1, SACM1L, SH3GLB1

telencephalon development ( GO:0021537 ):

HPRT1

cell cycle process ( GO:0022402 ):

BUB3, CCNG2, CUL5, HMGA2, MACF1, MAD2L1, PAFAH1B1, PSME3, SEH1L, SMC1A, TNKS, USP9X

cell cycle phase ( GO:0022403 ):

BUB3, CCNG2, CUL5, HMGA2, MAD2L1, PAFAH1B1, SEH1L, SMC1A, TNKS, USP9X

forebrain development ( GO:0030900 ):

CREB1, HPRT1, PAFAH1B1

cellular response to stress ( GO:0033554 ):

FOXO3, HIPK1, HMGB2, MAPK14, MORF4L1, NFE2L2, PTPN11, SIRT1, SMC1A, SSRP1, TLK1

cellular protein localization ( GO:0034613 ):

AP3S1, KPNB1, MACF1, NUP98, SH3GLB1, TLK1, TNKS, YWHAH, YWHAZ

embryonic hemopoiesis ( GO:0035162 ):

MLL, KAT6A, TGFBR2

regulation of programmed cell death ( GO:0043067 ):

CREB1, CUL5, FOXO3, GCH1, HIPK1, HSPD1, KRAS, MCL1, NRAS, PTPRF, SH3GLB1, SIRT1, YWHAZ

positive regulation of programmed cell death ( GO:0043068 ):

CUL5, FOXO3, GCH1, HIPK1, HSPD1, PTPRF, SH3GLB1

macromolecular complex subunit organization ( GO:0043933 ):

ETF1, GCH1, HMGB2, HPRT1, HSPD1, KPNB1, MLL, KAT6A, NUP98, PAK2, SEH1L, SRSF1, SMAD4, TRIM27, TSPYL1, WIPF1

establishment of protein localization ( GO:0045184 ):

AP3S1, ARF3, CANX, EPS15, KPNB1, MACF1, NUP98, POM121, RAB14, RAB1A, SEH1L, TLK1, TNKS, YWHAH, YWHAZ, ZDHHC17

positive regulation of transcription, DNA-dependent ( GO:0045893 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, NFE2L2, SMAD4, SMARCC1, TBL1XR1

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic pro ( GO:0045935 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, KAT6A, NFE2L2, SMAD4, SMARCC1, TBL1XR1, TNKS, YWHAH

positive regulation of transcription ( GO:0045941 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, KAT6A, NFE2L2, SMAD4, SMARCC1, TBL1XR1, YWHAH

positive regulation of transcription from RNA polymerase II promoter ( GO:0045944 ):

ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, SMAD4, TBL1XR1

glycerolipid metabolic process ( GO:0046486 ):

PAFAH1B1, PTPN11, SACM1L, SH3GLB1, SIRT1

intracellular transport ( GO:0046907 ):

AP3S1, ATXN1, KPNB1, MACF1, NUP98, PAFAH1B1, RAB14, TLK1, WIPF1, YWHAH, YWHAZ

organelle fission ( GO:0048285 ):

BUB3, CCNG2, HMGA2, MAD2L1, PAFAH1B1, SEH1L, SMC1A, USP9X

negative regulation of cellular component organization ( GO:0051129 ):

MAD2L1, PTPRF, RDX, YWHAH

positive regulation of nitrogen compound metabolic process ( GO:0051173 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, HPRT1, MAPK14, MLL, KAT6A, NFE2L2, SMAD4, SMARCC1, TBL1XR1, TNKS, YWHAH

positive regulation of RNA metabolic process ( GO:0051254 ):

AFF1, ATXN1, CBFB, CREB1, FOXO3, HMGB2, MAPK14, MLL, NFE2L2, SMAD4, SMARCC1, TBL1XR1

chromosome organization ( GO:0051276 ):

BMI1, BUB3, HMGA2, HMGB2, KDM3B, JMJD1C, MAD2L1, MLL, MORF4L1, KAT6A, SEH1L, SIRT1, SMARCC1, SMC1A, TBL1XR1, TLK1, TSPYL1

cellular macromolecule localization ( GO:0070727 ):

AP3S1, KPNB1, MACF1, NUP98, SH3GLB1, TLK1, TNKS, YWHAH, YWHAZ

N-Glycan biosynthesis ( hsa00510 ):

GANAB

Spliceosome ( hsa03040 ):

HNRNPK, SRSF1, U2SURP

MAPK signaling pathway ( hsa04010 ):

GNG12, KRAS, TAB2, MAPK14, MAX, NRAS, PAK2, RAP1B, TGFBR2

Oocyte meiosis ( hsa04114 ):

CALM1, MAD2L1, SMC1A, YWHAH, YWHAZ

VEGF signaling pathway ( hsa04370 ):

KRAS, MAPK14, NRAS

Adherens junction ( hsa04520 ):

PTPRF, SMAD4, TGFBR2, YES1

Long-term potentiation ( hsa04720 ):

CALM1, KRAS, NRAS, RAP1B

Neurotrophin signaling pathway ( hsa04722 ):

CALM1, FOXO3, KRAS, MAPK14, NRAS, PTPN11, RAP1B, YWHAH, YWHAZ

GnRH signaling pathway ( hsa04912 ):

CALM1, KRAS, MAPK14, NRAS

Pathways in cancer ( hsa05200 ):

CCDC6, JAK1, KRAS, MAX, NRAS, SMAD4, TGFBR2

Renal cell carcinoma ( hsa05211 ):

KRAS, NRAS, PAK2, PTPN11, RAP1B

Pancreatic cancer ( hsa05212 ):

JAK1, KRAS, SMAD4, TGFBR2

Glioma ( hsa05214 ):

CALM1, KRAS, NRAS

Prostate cancer ( hsa05215 ):

CREB1, CREB3L2, KRAS, NRAS

Melanoma ( hsa05218 ):

KRAS, NRAS

Bladder cancer ( hsa05219 ):

KRAS, NRAS

Chronic myeloid leukemia ( hsa05220 ):

KRAS, NRAS, PTPN11, SMAD4, TGFBR2

Non-small cell lung cancer ( hsa05223 ):

FOXO3, KRAS, NRAS