基因信息:
基因名称:
X-linked inhibitor of apoptosis
物种:
NCBI 基因身份号(GeneID):
331
官方基因符号(Symbol):
XIAP
曾用基因符号:
API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].

该基因有下列转录产物(transcript):
NM_001167.3
NM_001204401.1
产品:
产品编号 检测的转录产物
EXPHS92088 NM_001167.3 NM_001204401.1

说明:本公司表达谱PCR芯片产品使用该引物。