基因信息:
基因名称:
mitogen-activated protein kinase kinase kinase 5
物种:
NCBI 基因身份号(GeneID):
4217
官方基因符号(Symbol):
MAP3K5
曾用基因符号:
ASK1|MAPKKK5|MEKK5

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008].

该基因有下列转录产物(transcript):
NM_005923.3
产品:
产品编号 检测的转录产物
EXPHS125542 NM_005923.3

说明:本公司表达谱PCR芯片产品使用该引物。