基因信息:
基因名称:
caspase 3, apoptosis-related cysteine peptidase
物种:
NCBI 基因身份号(GeneID):
836
官方基因符号(Symbol):
CASP3
曾用基因符号:
CPP32|CPP32B|SCA-1

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].

该基因有下列转录产物(transcript):
NM_004346.3
NM_032991.2
产品:
产品编号 检测的转录产物
EXPHS6074004 NM_004346.3
EXPHS96091 NM_004346.3 NM_032991.2

说明:本公司表达谱PCR芯片产品使用该引物。