检测编号：NS0320104

基因 TCN2 与疾病

TCN2编码钴胺传递蛋白，将钴胺素（维生素B12）运到全身细胞内。钴胺素传递蛋白的缺乏使得机体缺少钴胺素，影响细胞生长、增殖及细胞能量代谢等。钴胺素对于新的血细胞的生成以及神经系统极为重要。

基因名称	基因全名	基因位置	外显子个数	CDS长度
TCN2	transcobalamin II	22q12.2	9	约2072 bp
基因摘要	This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].